Work packages > Work package 6

Start date or starting event: Month 1
Work package title: Improving knowledge on FMDV transmission between species and in recently vaccinated animals
Activity Type: RTD
Work Package Leader: CVI
Participants: CVI, IIL, KVI

Objectives

  • 1. To study the within-pen contact transmission in non-vaccinated cattle and in cattle vaccinated one week prior to contact-exposed challenge
  • 2. To study between-species pair-wise contact transmission between vaccinated and non-vaccinated sheep and cattle
  • 3. To study between-buffalo contact transmission in vaccinated buffalo calves at different times post vaccination (0, 7, 14, 21 and 35 dpv)
  • 4. To study early detection of virus penetration with or without clinical manifestation and correlation with the level of structural and NSP antibody detection in vaccinated and natural exposed animal herds (dairy farms, beef farms and small ruminant farms)
  • 5. To study the role of gazelles and wild boars in FMDV transmission under natural filed conditions
  • 6. To quantify the amount of FMDV in animal excretions and secretions originating from different species (e.g. cattle, sheep, pigs, buffalo, gazelles, wild boars)
This will enable quantification of the efficacy of FMD vaccination to prevent FMDV transmission in and between species.

Description of work

  • Task 1. Transmission experiments in vaccinated and non-vaccinated cattle one week post vaccination
  • Task 2. Transmission experiments between vaccinated and non-vaccinated sheep and cattle
  • Task 3. Transmission experiments in vaccinated and non-vaccinated buffalo
  • Task 4. Field studies
    •     4.1. Survey of structural and NSP antibodies in vaccinated herds in intermediate endemic areas in Israel
    •     4.2. The role of wild boars and gazelles in FMDV spread and transmission
  • Task 5. Quantification of FMDV in animal excretions and secretions

Deliverables (brief description and month of delivery)

  • 6.1. Report on the literature review on the possible quantitative role of various animal excretions and secretions in FMD virus transmission (M6)
  • 6.2. Report on the obtained knowledge on experimental quantification of FMDV in animal excretions and secretions, including on pathways for transmission and quantified transmission parameters that can be implemented in virus transmission models (see WP7) (M24)
  • 6.3. Report on the experimental quantification of FMDV transmission in cattle one, and possibly two, weeks after vaccination (M36)
  • 6.4. Report on the experimental quantification of FMDV transmission between cattle and sheep (M36)
  • 6.5. Report on the efficacy of FMD vaccines in buffalo (M36)
  • 6.6. Report on the analysis of field data on role of wildlife in FMDV transmission and on the early detection of FMDV in the livestock sector (M36)
  • 6.7. Peer-reviewed publications (M36)

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